Dr. Hai-Qiang Dai
AWARD RECIPIENT
Benyuan Young Investigator Program 2023
Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
Exploring the regulatory mechanism of the chromatin ring squeezing model mediated by mucin in the process of biological development and disease occurrence and development
Introduction
Dr. Hai-Qiang Dai graduated from Harbin Institute of Technology with a bachelor’s degree and then earned his Ph.D. from the Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences. From July 2017 to April 2021, he conducted postdoctoral research at Harvard Medical School/Boston Children’s Hospital. Since April 2021, Dr. Dai has been appointed as a research group leader and Ph.D. supervisor at the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences.
His research group focuses on mouse embryonic development and lymphocyte development, employing an interdisciplinary approach that integrates techniques from developmental biology, immunology, epigenetics, and 3D genomics. They aim to investigate the regulatory mechanisms underlying cohesin-mediated chromatin loop extrusion in the contexts of organismal development and the onset and progression of diseases. Their work aims to provide new theoretical basis for the prevention and treatment of human developmental disorders, autoimmune diseases, and lymphomas.
Selected Publications
1.Dai, H.-Q.#*, Hu, H. #, Lou, J., Ye, A.Y., Ba, Z., Zhang, X., Zhang, Y., Zhao, L., Yoon, H.S., Chapdelaine-Williams, A.M., Kyritsis, N., Chen, H., Johnson, K., Lin, S.G., Conte, A., Casellas, R., Lee, C.-S.*, Alt, F.W.* (2021). Loop extrusion mediates physiological Igh locus contraction for RAG scanning. Nature. 590, 338–343.
2.Dai, H.-Q.#, Liang, Z.#, Chang, A.M.#, Chapdelaine-Williams, A.M., Alvarado, B., Pollen, A.A., Alt, F.W., Schwer, B. (2020). Direct analysis of brain phenotypes via neural blastocyst complementation. Nature Protocols. 15 (10), 3154-3181.
3.Dai, H.-Q.#, Wang, B.#, Yang, L.#, Chen, J.#, Zhu, G., Sun, M., Ge, H., Wang, R., Chapman, D.L., Tang, F., Sun, X., Xu, G.-L. (2016). TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signaling. Nature. 538, 528-532.
benyuancharity@163.com
