Dr. Haifeng Wang

AWARD RECIPIENT

Benyuan Young Investigator Program 2021

Tsinghua University

Genetic Lineage Tracing and Tissue Regeneration

Introduction

Dr. Haifeng Wang. Assistant Professor at Tsinghua University. Dr. Wang received her Master’s degree in biological science from Tsinghua University. She continued her doctoral research in biochemistry, molecular, cellular, and developmental biology at the University of California in Davis and later assumed her postdoctoral work at Stanford University. She joined Tsinghua University as an assistant professor in 2021. Her team is particularly interested in developing and applying CRISPR toolkits to study the function and control of 3D genome organization and transcriptome dynamics during the development and disease phases. Her background in cell biology and bioengineering has helped her to develop several techniques for the study of spatial structure-function relationships and the dynamics of the 3D genome. From technology development to biological and clinical applications, Dr. Wang’s team is dedicated to the discovery of how spatial genome organization and nuclear architecture regulate gene activity and cellular function, the molecular mechanisms controlling the changes in the 3D genome organization and transcriptome dynamics, and the role of spatial genome organization and transcriptional dynamics in the development and disease stages.

 

Selected Publications

Wang ,H., Han, M., and Qi, L.S. (2021). Engineering 3D genome organization. Nat Rev Genet, 22, 343–360. Wang, H., Nakamura, M., Abbott, T.R., Zhao, D., Luo, K., Yu, C., Nguyen, C.M., Lo, A., Daley, P.T., La Russa, M., et al. (2019). CRISPR-mediated live imaging of genome editing and transcription. Science 365, 1301–1305. Wang, H., Xu, X., Nguyen, C.M., Liu, Y., Gao, Y., Lin, X., Daley, P.T., Kipniss, N.H., La Russa, M., and Qi, L.S. (2018). CRISPR-mediated programmable 3D genome positioning and nuclear organization. Cell, 175, 1405–1417. e14.