Dr. Junhao Zhu
AWARD RECIPIENT
Benyuan Young Investigator Program 2024
Institute of Microbiology, Chinese Academy of Sciences (IMCAS)
Mechanism and evolution of phenotypic drug resistance of Mycobacterium tuberculosis and other respiratory pathogens
Introduction
Dr. Zhu earned a Bachelor’s degree from the School of Life Sciences at Peking University and a Ph.D. in Cell Biology in 2017 through a joint program between Peking University and Tsinghua University. Following doctoral studies, he conducted postdoctoral research at the Harvard T.H. Chan School of Public Health and was appointed as a Research Scientist there in 2021. In 2023, he started his lab at the Institute of Microbiology, Chinese Academy of Sciences (IMCAS).
His lab focuses on investigating phenotypic drug resistance mechanisms and evolutionary trajectories of human pathogens, such as Mycobacterium tuberculosis, using multidisciplinary approaches including high-throughput genetics, computer vision, and next-generation sequencing.
Selected Publications
1.Won H, Zinga S, Kandror O, Akopian T, Wolf I, Schweber J, Schmid E, Chao M, Waldor M, Rubin E#, Zhu J# (2024), Targeted protein degradation in mycobacteria uncovers antibacterial effects and potentiates antibiotic efficacy. Nature Communications, 15, 4065.
2.Liu Q, Zhu J*, Dulberger C, Stanley S, Wilson,S, Chung E, Wang X, Culviner P, Liu Y, Hicks N, Babunovic G, Giffen S, Aldridge B, Garner E, Rubin E, Chao M, Fortune S# (2022). Tuberculosis treatment failure associated with evolution of antibiotic resilience. Science, 378, 1111-1118.
3.Zhu J*, Wolf I, Dulberger C, Won H, Kester J, Judd J, Wirth S, Clark R, Li Y, Luo Y, Gray T, Wade J, Derbyshire K, Fortune S, Rubin E# (2021). Spatiotemporal localization of proteins in mycobacteria. Cell Reports, 37(13), 110154.
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