Dr. Yushen Du
AWARD RECIPIENT
Benyuan Young Investigator Program 2021
Zhejiang University
Viral immunity, quantitative high-throughput immunoomics
Introduction
Dr. Yushen Du. Assistant Professor at Zhejiang University. Dr. Du was trained in an M.D. program offered jointly by Zhejiang University and UCLA. Subsequently, she worked as an assistant professor for a year at UCLA, joining Zhejiang University as an assistant professor in 2021. Her unique physician-scientist experience drives her particular interest in translating bench-side results into clinical applications. Her predominant research goal involves precisely modulating the immune system using novel vaccine strategies, building on a comprehensive evaluation of the immune compartments. She plans to employ high-resolution profiling technologies to quantitatively evaluate the temporal and spatial dynamics of the immune response. Viral diseases (influenza and COVID-19) and cancer (lung and colorectal cancer) will be her two principal focus areas.
Selected Publications
Du, Y., Xin, L., Shi, Y., Zhang, T.H., Wu, N.C., Dai, L., Gong, D., Brar, P., Shu, S., Luo, J., et al. (2018). Genome-wide identification of interferon-sensitive mutations enables influenza vaccine design. Science 359, 290–296. Du, Y., Hultquist, J.F., Zhou, Q., Olson, A., Tseng, Y.W., Zhang, T.H., Hong, M.Y., Tang, K.J., Chen, L.B., Meng, X.Z., et al. (2020). mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1. Nat Commun 11, 2249. Shen, Y., Tang, K.J., Chen, D.D., Hong, M.Y., Sun, F.F., Wang, S.S., Ke, Y.H., Wu, T.T., Sun, R., Qian, J., et al. (2021). Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation. Cell Rep 35, 109272.
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