Dr. Zhaoqing Ba
AWARD RECIPIENT
Benyuan Young Investigator Program 2022
National Institute of Biological Sciences (NIBS), Beijing, China
Immune diversity and multiscale immunomics
Introduction
Dr. Ba is currently a PI at NIBS. He completed his B.S. in Biotechnology at Jiangnan University (National Base of Life Science & Biotechnology Education Program). He obtained his Ph.D. in Biochemistry and Molecular Biology under a joint program by NIBS and Beijing Normal University. He then joined Harvard Medical School and Boston Children’s Hospital as a Postdoctoral Fellow and later as an Instructor/Research Associate. He focused on delineating the mechanisms whereby antibody genes are assembled in mammalian adaptive immunity by developing innovative approaches. His independent lab is interested in elucidating the mechanism and significance of immune diversity through developing and employing multiscale immunomics methods. He hopes to address problems of both fundamental and translational importance to benefit human health.
Selected Publications
1. Ba, Z.*#, Lou, J.*, Ye, A.Y., Dai, H.-Q., Dring, E.W., Lin, S.G., Jain, S., Kyritsis, N., Kieffer-Kwon, K.-R., Casellas, R.#, and Alt, F.W.# (2020). CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning. Nature 586, 305-310.
2. Jain, S.*, Ba, Z.*, Zhang, Y., Dai, H.-Q., and Alt, F.W.# (2018). CTCF-Binding Elements Mediate Accessibility of RAG Substrates During Chromatin Scanning. Cell 174, 102-116.
3. Lin, S.G.*, Ba, Z.*, Du, Z.*, Zhang, Y., Hu, J.#, and Alt, F.W.# (2016). Highly Sensitive and Unbiased Approach for Elucidating Antibody Repertoires. Proc. Natl. Acad. Sci. USA 113, 7846-7851.
4. Ba, Z.*, Meng, F.-L.*, Gostissa, M.*, Huang, P.-Y., Ke, Q., Wang, Z., Dao, M.N., Fujiwara, Y., Rajewsky, K., Zhang, B.#, and Alt, F.W.# (2015). A Rapid Embryonic Stem Cell-Based Mouse Model for B-cell Lymphomas Driven by Epstein-Barr Virus Protein LMP1. Cancer Immunol. Res. 3, 641-649.
5. Wei, W.*, Ba, Z.*, Gao, M., Wu, Y., Ma, Y., Amiard, S., White, C.I., Rendtlew Danielsen, J.M., Yang, Y.- G., and Qi, Y.# (2012). A Role for Small RNAs in DNA Double-Strand Break Repair. Cell 149, 101-112.
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