
Dr. Xushen Xiong
AWARD RECIPIENT

Benyuan Young Investigator Program 2024

Liangzhu Laboratory of Zhejiang University and the Second Affiliated Hospital of Zhejiang University School of Medicine

Dissection of human polygenic disease using computational biology and artificial intelligence (AI) approaches
Introduction
Dr. Xushen Xiong completed his undergraduate study at Huazhong University of Science and Technology, and obtained his PhD degree at Peking University in 2019, after which he joined MIT Computer Science & Artificial Intelligence Laboratory (CSAIL) for a postdoc training. He joined Zhejiang University School of Medicine Liangzhu Laboratory in 2022 as a Principal Investigator for his independent research.
Dr. Xushen Xiong has been devoted to explore the biological mechanisms of epitranscriptomics and epigenomics in human polygenic diseases using interdisciplinary approaches, including statistical genetics, artificial intelligence (AI), and experimental biology. His research aims to provide multiple levels of molecular targets for the prediction, molecular diagnosis, and treatment of polygenic diseases. Dr. Xiong has published papers in journals such as Cell, Nature Genetics (2 papers), Nature Machine Intelligence, and Cell Genomics, as a corresponding or first author (including co-first).
Selected Publications
1. Jialin He#, Lei Xiong#,*, Shaohui Shi, Chengyu Li, Kexuan Chen, Qianchen Fang, Jiuhong Nan, Ke Ding, Yuanhui Mao, Carles A. Boix, Xinyang Hu, Manolis Kellis, Jingyun Li, Xushen Xiong*. Deep learning modeling of ribosome profiling reveals regulatory underpinnings of translatome and interprets disease variants. Nature Machine Intelligence (2024)
2. Chengyu Li#, Kexuan Chen#, Qianchen Fang, Shaohui Shi, Jiuhong Nan, Jialin He, Yafei Yin, Xiaoyu Li, Jingyun Li, Lei Hou, Xikun Han*, Xushen Xiong*. Crosstalk between epitranscriptomic and epigenomic modifications and its implication in human diseases. Cell Genomics (2024)
3. Xushen Xiong#, Benjamin T. James#, Carles A. Boix#, Yongjin Park, Kyriaki Galani, Na Sun, Lei Hou, Li-Lun Ho, Julio Mantero, Hansruedi Mathys, David A. Bennett, Li-Huei Tsai, Manolis Kellis. Single-cell epigenomic dissection of Alzheimer's disease pinpoints causal genetic variants and reveals epigenome erosion. Cell (2023)